Moss rose to fame in the early 1990s. She is known for her waifish figure, and her role in size zero fashion. She is also famous for her controversial private life, high profile relationships, party lifestyle, and drug use. In 2007, she came 2nd on the Forbes top-earning models list, estimated to have earned $9 million in one year. Aside from modelling, Moss has started several ventures, including her own clothing line and various musical projects.
She was found at the age of 14 by Sarah Doukes of the Storm Modeling Agency in 1988 while in an airport. Moss' career began when Corinne Day shot black and white photographs of her for British magazine The Face, in a photo shoot titled "The Third Summer of Love".
Moss has been a supporter of the Breakthrough Breast Cancer charity, and in the 1990s featured in one of their target t-shirt campaigns. She also supported War Child. Moss also designed a charm in a necklace for Wallis in 2007 in aid of Cancer Research UK and said "I am happy to give my support to help fund crucial research, as so many lives are affected by this terrible disease".
She has also helped to launch the SamandRuby charity in March 2006. The charity was started to provide funding for the education and shelter of Thai children. The SamandRuby organisation is named after a friend of Moss's Samantha Archer Fayet and her 6 month old daughter Ruby Rose who were killed by the Tsunami while visiting Thailand. Moss also supports the Elton John AIDS Foundation, the Hoping Foundation, the Lucie Blackman Trust, Make Poverty History, Comic Relief and Homes of Hope which her close friend Sadie Frost also supports.